منابع مشابه
Mending a Faltering Heart.
More people die every year from ischemic heart disease than any other disease. Because the human heart lacks sufficient ability to replenish the damaged cardiac muscles, extensive research has been devoted toward understanding the homeostatic and regenerative potential of the heart and to develop regenerative therapies for heart disease. Here, we discuss recent advances in the understanding of ...
متن کاملMending a broken heart: the role of mitophagy in cardioprotection.
The heart is highly energy dependent with most of its energy provided by mitochondrial oxidative phosphorylation. Mitochondria also play a role in many other essential cellular processes including metabolite synthesis and calcium storage. Therefore, maintaining a functional population of mitochondria is critical for cardiac function. Efficient degradation and replacement of dysfunctional mitoch...
متن کاملPharmacogenomics and the Failing Heart
n Samuel Beckett’s play, Waiting for Godot, the characters ait by a country roadside for a person named Godot, who ever arrives (1). Godot’s conspicuous absence throughout he play has fostered a variety of different religious, philoophical, and psychoanalytical interpretations, and has led o the use of the phrase “waiting for Godot” as an expression or waiting for someone or something that will...
متن کاملCardiac regeneration in vivo: mending the heart from within?
A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlyi...
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ژورنال
عنوان ژورنال: Aging
سال: 2019
ISSN: 1945-4589
DOI: 10.18632/aging.101879