Memory phenotype Tfh cells are homeostatically maintained and are important for the development of germinal centers and B cell responses to virus infection

Abstract Memory phenotype (MP) CD4 T cells that develop in the absence of overt antigen stimulation are important for both innate and adaptive immune responses. Although pathogen specific MP have been found to function effectively against infection, it is not known if Tfh can also be developed stimulation. Here, we demonstrate In addition FR4+, a mark induced memory cells, expressed high levels Egr2. The development defective CD2-Egr2/3−/− mice. share similar features phenotypes epigenetics with induce germinal center formation B Thus, regulated by Egr2/3 pathway component immunity. Medical Research Council UK (MR/N00096X/1), Barts Charity (MGU0463)