Membrane Potentials at Zero Current

The “Funny” Current (If) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker Cells

Recent clinical trials have shown that ivabradine (IVA), a drug that inhibits the funny current (I(f)) in isolated sinoatrial nodal cells (SANC), decreases heart rate and reduces morbidity and mortality in patients with cardiovascular diseases. While IVA inhibits I(f), this effect has been reported at essentially unphysiological voltages, i.e., those more negative than the spontaneous diastolic...

Membrane Potentials and Action Potentials

Electrical potentials exist across the membranes of virtually all cells of the body. In addition, some cells, such as nerve and muscle cells, are capable of generating rapidly changing electrochemical impulses at their membranes, and these impulses are used to transmit signals along the nerve or muscle membranes. In other types of cells, such as glandular cells, macrophages, and ciliated cells,...

Membrane Potentials and Colloidal Behavior

There is no real point of conflict between our views and those expressed by Professor Hill. The mere agreement of the figures for P.D., considered abstractly and apart from experimental conditions, is not a proof of the existence of a Donnan equilibrium. For example, in an experiment in which the protein were omitted altogether there would also be agreement of the r.D. values, for each would be...

Membrane Potentials and Colloidal Behavior

An answer has been given by Hitchcock 1 to a recent criticism by myself 2 of an argument vigorously exploited by Loeb in favor of his theory of colloidal behavior. Hitchcock suggests that this criticism rests upon a misunderstanding, but he admits the validity of my main contentions, and I am happy to note that Loeb has taken heed of them in two recent papers. I have no quarrel with many of the...

Membrane potentials in Amoeba proteus.