منابع مشابه
Membrane traffic: Cycling lipids
One of the more fascinating problems in biology is to understand the nerve signalling that enables us to think and feel. The transmission of nerve impulses across synapses is accomplished by the release of signalling molecules, known as neurotransmitters, at nerve terminals. Neurotransmitters are stored in synaptic vesicles and, after the nerve has received the appropriate stimulus, they are re...
متن کاملVesicular traffic at the cell membrane regulates oocyte meiotic arrest.
Vertebrate oocytes are maintained in meiotic arrest for prolonged periods of time before undergoing oocyte maturation in preparation for fertilization. Cyclic AMP (cAMP) signaling plays a crucial role in maintaining meiotic arrest, which is released by a species-specific hormonal signal. Evidence in both frog and mouse argues that meiotic arrest is maintained by a constitutively active G-protei...
متن کاملEndosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet.
The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. Increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and apparently also exit, endosomal compartments via both vesicular and non-vesicular m...
متن کاملVesicular Traffic: A Rab SANDwich
The small GTPases Rab5 and Rab7 mark temporally distinct but sequentially connected stages in phagosome maturation, but the mechanism underlying the transition between these stages has been unclear. Recent studies in Caenorhabditis elegans have now uncovered a new protein complex that connects Rab5 to Rab7.
متن کاملRab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane
Small GTP-binding proteins of the rab family have been implicated as regulators of membrane traffic along the biosynthetic and endocytic pathways in eukaryotic cells. We have investigated the localization and function of rab8, closely related to the yeast YPT1/SEC4 gene products. Confocal immunofluorescence microscopy and immunoelectron microscopy on filter-grown MDCK cells demonstrated that, r...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2004
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2004.06.004