Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance

Aminoglycoside resistance in Pseudomonas aeruginosa.

anthelmintics resistance; how to overcome it?

many parasitic helminthes of veterinary importance have genetic features that favor development of anthelmintic resistance, this becoming a major worldwide constrain in livestock production. the de-velopment of anthelmintic resistance poses a large threat to future production and welfare of grazing animals. development of variable degrees of resistance among different species of gastrointestina...

Strategies to overcome biofilm resistance

Biofilm have been found to be involved in a wide variety of microbial infections in the body, by one estimate 80% of all infections. A number of anti-biofilm strategies have emerged to prevent the colonization and formation of biofilms. However, there are four main intervention strategies in clinical practice for biofilm-associated infections. The first strategy is to prevent the initial microb...

Aminoglycoside resistance mediated by the bifunctional enzyme 6'-N-aminoglycoside acetyltransferase-2"-O-aminoglycoside phosphotransferase.

The expression of the bifunctional aminoglycoside inactivating enzyme 6'-N-aminoglycoside acetyltransferase-2"-O-aminoglycoside phosphotransferase is the most important mechanism of high-level aminoglycoside resistance in Staphylococcus and Enterococcus. The enzyme is unique because it presents two different aminoglycoside-modifying activities located in different regions of the molecule. The g...

Aminoglycoside - Induced Modifications of Membrane Phosphoinositide Metabolism

Several lines of evidence indicate that the first steps in the pathogenesis of anlinoglycoside nephrotoxicity involve the accumulation of the antibiotic in the proximal tubule where it interacts with the plasma membrane of epithelial cells' 2) . In brush border membranes, acidic phospholipids and most particularly phosphoinositides, phosphatidylinositol (PI), phosphatidylinositol-4phosphate (PI...