Melchior Díaz—The Forgotten Explorer

Dyggve-Melchior-Clausen syndrome.

Dyggve-Melchior-Clausen syndrome (DMC) is a rare, dwarfing, skeletal dysplasia characterised by a coarse facies, bulky jaws, short trunk, and barrel chest. Significant radiographical changes include platyspondyly and dysplasia of the epiphyses and metaphyses of the proximal limb bones. Dislocation of the hips and malalignment of the spine and knees are variable features. Inheritance is autosoma...

Dyggve melchior clausen syndrome.

Dyggve Melchior Clausen syndrome is a rare autosomal recessive disorder, characterized by progressive spondylo epi metaphyseal dysplasia associated with mental retardation. The clinical and radiological findings resembles Morquio disease at the onset of condition, which may hinder its diagnosis. Two siblings with chatacteristic clinical (progressive postnatal dwarfism and mental retardation) an...

Frauke Melchior: How SUMO wrestles other proteins

F rauke Melchior vividly remembers the afternoon when, as a postdoc in Larry Gerace's laboratory , she developed the fi lm from a particular experiment. It proved that her hypothesis was correct. The mysterious mobility shifts she'd observed in earlier experiments were due to a novel protein modifi cation: addition of the peptide she would name " small ubiquitin-related modifi er " (SUMO) (1). ...

Space Explorer

Explorer MOSAIC

Background: The recent availability of complete sequences for numerous closely related bacterial genomes opens up new challenges in comparative genomics. Several methods have been developed to align complete genomes at the nucleotide level but their use and the biological interpretation of results are not straightforward. It is therefore necessary to develop new resources to access, analyze, an...