Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions.

This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methyl...

Chloroplastic biosynthesis of melatonin and its involvement in protection of plants from salt stress

Within the chloroplasts reactive oxygen species (ROS) are generated during photosynthesis and stressful conditions. Excessive ROS damages chloroplasts and reduces photosynthesis if not properly detoxified. In this current study, we document that chloroplasts produce melatonin, a recently-discovered plant antioxidant molecule. When N-acetylserotonin, a substrate for melatonin synthesis, was fed ...

Protection from oxidative stress in transgenic plants.

37 Karpinksi. S. (1994) I’h.1). Thesis. Swedish University of Agricultural Sciences. limea Greer. S. and I’erham, K. N. (1986) Biochemistry 25. 2736-2742 Kunert, K. J., Cresswell. C. F., Schmidt. A.. Mullineaux, 1’. M. and Foyer, C. H. (1990) Arch. Hiochem. Hiophys. 282.233-238 Foyer. C. H.. Lelandais. M., Galap, C. and Kunert, K. J. (1991) I’lant I’hysiol. 97.803-872 Aono. M., Kubo. A., Saji9 ...

Melatonin oxidative stress and neurodegenerative diseases.

Oxidative Stress is implicated as one of the primary factors that contribute to the development of neurodegenerative diseases like Alzheimer's Disease, Parkinsonism and neurological conditions like epileptic seizures, stroke, brain damage, neurotrauma etc. The increased formation and release of oxygen free radicals coupled with the rather low antioxidative potential of the central nervous syste...

Protection against Oxidative Stress