Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner
نویسندگان
چکیده
منابع مشابه
A Paracrine Regulator of Vascular Calcification and Smooth Muscle Phenotype
Cellular and molecular similarities between orthotopic versus heterotopic mineral deposition are beginning to emerge. During bone formation, the major orthotopic venue, two general mechanisms drive tissue mineralization1 (Table). With endochondral ossification, an avascular cartilaginous skeletal template is first established by chondrocytes; this cartilage template calcifies and is subsequentl...
متن کاملAgeing and vascular ageing.
There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance. Arterial compliance can be measured by different parameters like pulse wave velocity, augmentation index, and systemic arterial complian...
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Vascular calcification is a frequent cause of morbidity and mortality in patients with CKD and the general population. The common association between vascular calcification and osteoporosis suggests a link between bone and vascular disorders. Because microRNAs (miRs) are involved in the transdifferentiation of vascular smooth muscle cells into osteoblast-like cells, we investigated whether miRs...
متن کاملInorganic pyrophosphate: a paracrine regulator of vascular calcification and smooth muscle phenotype.
Cellular and molecular similarities between orthotopic versus heterotopic mineral deposition are beginning to emerge. During bone formation, the major orthotopic venue, two general mechanisms drive tissue mineralization1 (Table). With endochondral ossification, an avascular cartilaginous skeletal template is first established by chondrocytes; this cartilage template calcifies and is subsequentl...
متن کاملParacrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma.
Neuroblastoma, a tumor of peripheral neural crest origin, numbers among the most common childhood cancers. Both amplification of the proto-oncogene MYCN and increased neoangiogenesis mark high-risk disease. Because angiogenesis is regulated by phosphatidylinositol 3-kinase (PI3K), we tested a clinical PI3K inhibitor, NVP-BEZ235, in MYCN-dependent neuroblastoma. NVP-BEZ235 decreased angiogenesis...
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ژورنال
عنوان ژورنال: Bone Reports
سال: 2020
ISSN: 2352-1872
DOI: 10.1016/j.bonr.2020.100343