Medulloblastoma: Clinical presentation

Medulloblastomas present generally a-specifically as a fast-evolving posterior fossa tumor. Medical literature is poor concerning clinical features of medulloblastomas and their potential significance. In the study, we reviewed 91 pediatric observations treated in Lille between 1997 2017. Clinical epidemiological variables were collected intercorrelated. They also compared with anatomical pathological findings, outcome, aim defining clinical-pathological entities. We group 32 cases ependymoma 130 cerebellar astrocytoma during same period. found that medulloblastomas, M/F ratio was higher diagnostic delay shorter than astrocytomas. Also, mean age older ependymomas. Intracranial hypertension constant; further observed altered general status common (16.5%) correlated metastatic delineated two clusters: “nodular” cluster, which associates young age, cerebello-pontine angle tumor, herniation, desmoplastic tumor predisposition syndrome; “metastatic” status, initial metastases, hydrocephalus, delay. Meticulous collection data at phase integral part oncological evaluation, search for genetic prognostic risk factors, then permits us to define