Medicine embraces nano: diagnostics to delivery

Precision medicine, technologies, and molecular diagnostics

Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...

Nano-structured Vaccine Delivery

The nano-structured vaccine delivery system, containing tomatine, n-octyl-β-Dglucopyranoside (OGP), phosphatidylethanolamine (PE), cholesterol, and ovalbumin (OVA), was examined in the present study. Transmission electron microscopy (TEM) and fluorescence microscopy were carried out to examine the nano-structures of this complex vaccine delivery system and its interactions with the antigen-pres...

Light Scattering Shape Diagnostics for Nano-Agglomerates

Light Scattering Shape Diagnostics for NanoAgglomerates George W. Mulholland a b , Lei Zhou b , Michael R. Zachariah a b , William R. Heinson c , Amit Chakrabarti c & Christopher Sorensen c a Department of Mechanical Engineering, University of Maryland, College Park, Maryland, USA b Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, USA c De...

Companion diagnostics at the intersection of personalized medicine and healthcare delivery.

Lipids, curvature, and nano-medicine*

The physical properties of the lamellar lipid-bilayer component of biological membranes are controlled by a host of thermodynamic forces leading to overall tensionless bilayers with a conspicuous lateral pressure profile and build-in curvature-stress instabilities that may be released locally or globally in terms of morphological changes. In particular, the average molecular shape and the prope...