Medication-Related Osteonecrosis of the Jaw (MRONJ)

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious disease that can affect person's upper or lower jaw.1Feng Z Ann J Zhang Y Factors influencing severity medication-related jaw: retrospective study.J Oral Maxillofac Surg. 2021; 79: 1684-1689Abstract Full Text PDF Scopus (4) Google Scholar First described in 2002, it progressive death jawbone person exposed to medication known increase risk disease, absence previous radiation treatment. Such medications are used treat osteoporosis (brittle bones) cancer such as multiple myeloma. The most common bisphosphonates.2Ruggiero SL Dodson TB Fantasia et al.American Association and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis Jaw—2014 Update.J 2014; 72 (1938)Google MRONJ usually presents with bone mouth (Figure 1). This present an area dead after tooth extraction trauma. Some signs include:•Jaw pain•Redness your gum•Exposed bone•Non-healing socket•Numbness jaw•Loose teeth•A bad taste mouth•Swelling face affected gum You should contact dentist oral maxillofacial surgeon if you develop any these symptoms have concerns. best way prevent avoid having extracted often this cannot be avoided. Gum infection make patients more likely get MRONJ. Regular dental examination keeping up good health before, during, prescription very important need for emergent Ideally, teeth placement implants performed before starting medications. It may recommended stop taking sometime Your will coordinate physician. Sometimes treatment delayed until negative effect anti-resorptive reduced. If patient diagnosed MRONJ, surgery Hygiene measures reassessed reinforced order progression. steps include:•Daily irrigation antimicrobial rinse.•Antibiotics control progression disease.•Surgical intervention remove some advanced cases.•In patients, removable appliance cover protect sometimes recommended.•If dentures worn, minimizing irritation soft tissues done. RE: MEDICATION-RELATED OSTEONECROSIS OF THE JAW (MRONJ)Journal SurgeryVol. 80Issue 1PreviewWe read great interest contribute section “Simply Put: JOMS Information Patients” named “Medication-Related Jaw (MRONJ)” by Elie M. Ferneini.1 Full-Text