Medication discovery for addiction: Translating the dopamine D3 receptor hypothesis
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چکیده
منابع مشابه
Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis
The dopamine D3 receptor (D3R) is a target for developing medications to treat substance use disorders. D3R-selective compounds with high affinity and varying efficacies have been discovered, providing critical research tools for cell-based studies that have been translated to in vivo models of drug abuse. D3R antagonists and partial agonists have shown especially promising results in rodent mo...
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Psychostimulant abuse is a serious social and health problem, for which no effective treatments currently exist. A number of review articles have described predominantly 'clinic'-based pharmacotherapies for the treatment of psychostimulant addiction, but none have yet been shown to be definitively effective for use in humans. In the present article, we review various 'hypothesis'- or 'mechanism...
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Methamphetamine is a potent psychomotor stimulant and a major drug of abuse. There is currently no effective medication available for treatment for methamphetamine addiction. The present study investigated the role of the dopamine D3 receptor on IV methamphetamine self-administration and its effect on methamphetamine induced neurochemical changes. Acute administration of the putative D3 recepto...
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Dopamine (DA) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. The dopaminergic system is the primary therapeutic target in the treatment of Parkinson’s disease (PD), drug addiction and schizophrenia. Notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...
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Functional models for the dopamine D3 receptor N. Griffon*II, F. Sautel*, C. Pilon*, D. Levesque*, P. SokolofP, 1.-C. Schwartz*, J. Diazt, P. Simon*, J. Costentin*, A. Mann§ and C. G. Wermuthg *Unite de Neurobiologie et Pharrnacologie, Centre Paul Broca de I'INSERM, Paris, France, tLaboratoire de Physiologie, Universite Rene Descarte, Paris, France, SLaboratoire de Pharrnacologie et Physiologie...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2012
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2012.06.023