منابع مشابه
Sequential Medical Trials, 2nd Edition
morphology at the macroscopic, microscopic and ultrastructural levels. Wherever appropriate, he goes from structure into function and introduces concepts involving histochemistry, biochemistry, biophysics and bioengineering. The book is easy to read and presents the material in a very concise fashion and focuses upon the need for more extensive microcirculatory research. As an introduction to t...
متن کاملBias and Conditioning in Sequential Medical Trials
Randomized Controlled Trials (RCTs) are currently the gold standard within evidencebased medicine. Usually, they are conducted as sequential trials allowing for monitoring for early signs of effectiveness or harm. However, evidence from early stopped trials is often charged with being biased towards implausibly large effects (e.g., Bassler et al. 2010). To our mind, this skeptical attitude is u...
متن کاملThe Medical Adviser and General Practitioner Trials
medicines will not appear without years of hard work and co-operation between practising doctors and their colleagues in the pharmaceutical industry. I have already written on the reasons why I left general practice and entered the pharmaceutical industry.1 In this article I will discuss the background against which the medical adviser works and argue the case for general practitioner trials. S...
متن کاملQuality Assessment of Published Clinical Trials of Mashhad University of Medical Sciences Between 1999 and 2018
Background and Objectives: Clinical trials are used extensively in the compilation of systematic review studies and clinical guidelines. Critical appraisal of articles is a part of systematic review writing and also effective in citation. This study aimed to evaluate quality of randomized clinical trial articles of Mashhad University of Medical Sciences with consideration report of randomized, ...
متن کاملEvaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1889
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(00)64144-2