Mediation of adenylyl cyclase sensitization by PTX-insensitive G?oA, G?i1, G?i2or G?i3
نویسندگان
چکیده
منابع مشابه
Mediation of adenylyl cyclase sensitization by PTX-insensitive GαoA, Gαi1, Gαi2 or Gαi3
Chronic activation of mu-opioid receptors, which couple to pertussis toxin-sensitive Gai/o proteins to inhibit adenylyl cyclase (AC), leads to a compensatory sensitization of AC. Pertussis toxin-insensitive mutations of Gai/o subtypes, in which the pertussis toxin-sensitive cysteine is mutated to isoleucine (Ga i=o), were used to determine whether each of the Gai/o subtypes is able to mediate s...
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Whereas acute stimulation of G i/o-coupled receptors inhibits the activity of adenylyl cyclase, a delayed consequence of persistent activation of the receptors is heterologous sensitization, an enhanced responsiveness of adenylyl cyclase to activators such as forskolin or agonists of G s-coupled receptors. G s-insensitive mutants of adenylyl cyclase type V were used to test the hypothesis that ...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2006
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2006.04176.x