Medial calcification in the arterial wall of smooth muscle cell‐specific Smpd1 transgenic mice: A ceramide‐mediated vasculopathy
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چکیده
منابع مشابه
Smooth Muscle–Selective Nuclear Factor‐κB Inhibition Reduces Phosphate‐Induced Arterial Medial Calcification in Mice With Chronic Kidney Disease
BACKGROUND Hyperphosphatemia is a major factor promoting the formation of arterial medial calcification in chronic kidney disease (CKD). However, arterial medial calcification begins to occur during the early stages of CKD, when hyperphosphatemia is not yet apparent. It is predicted that other factors also play a role. The aim of the present study was to determine the role of pro-inflammatory n...
متن کاملMedial Arterial Calcification
Peripheral arterial disease (PAD) refers to occlusion or narrowing of the upper and lower extremity arteries, causing insufficient blood flow to the limbs. Patients with PAD often present with symptoms, such as claudication, ischemic rest pain, ischemic ulcerations, and limb loss. These patients are also highly predisposed to cardiovascular morbidity and mortality. PAD is underdiagnosed, and li...
متن کاملMedial Arterial Calcification
Peripheral arterial disease (PAD) refers to occlusion or narrowing of the upper and lower extremity arteries, causing insufficient blood flow to the limbs. Patients with PAD often present with symptoms, such as claudication, ischemic rest pain, ischemic ulcerations, and limb loss. These patients are also highly predisposed to cardiovascular morbidity and mortality. PAD is underdiagnosed, and li...
متن کاملMedial Arterial Calcification
Peripheral arterial disease (PAD) refers to occlusion or narrowing of the upper and lower extremity arteries, causing insufficient blood flow to the limbs. Patients with PAD often present with symptoms, such as claudication, ischemic rest pain, ischemic ulcerations, and limb loss. These patients are also highly predisposed to cardiovascular morbidity and mortality. PAD is underdiagnosed, and li...
متن کاملImplication of molecular vascular smooth muscle cell heterogeneity among arterial beds in arterial calcification
Vascular calcification is a strong and independent predictive factor for cardiovascular complications and mortality. Our previous work identified important discrepancies in plaque composition and calcification types between carotid and femoral arteries. The objective of this study is to further characterize and understand the heterogeneity in vascular calcification among vascular beds, and to i...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2019
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.14761