MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs
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MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs
The RNA polymerase II mediator complex subunit 12 (MED12) is frequently mutated in human cancers, and loss of MED12 has been shown to induce drug resistance through activation of transforming growth factor-β receptor (TGF-βR) signaling. We identified MED12 as a substrate for coactivator-associated arginine methyltransferase 1 (CARM1). Not only are the expression levels of CARM1 and MED12 positi...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2015
ISSN: 2375-2548
DOI: 10.1126/sciadv.1500463