Mechanochemical Synthesis of Rosuvastatin Intermediates by Liquid-Assisted Wittig Reaction
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چکیده
منابع مشابه
Liquid-assisted grinding and ion pairing regulates percentage conversion and diastereoselectivity of the Wittig reaction under mechanochemical conditions
Mechanochemistry is maturing as a discipline and continuing to grow, so it is important to continue understanding the rules governing the system. In a mechanochemical reaction, the reactants are added into a vessel along with one or more grinding balls and the vessel is shaken at high speeds to facilitate a chemical reaction. The dielectric constant of the solvent used in liquid-assisted grindi...
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A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.
متن کاملSynthesis of calcium carbide-derived carbon by mechanochemical reaction of calcium carbide with sulfur, iron sulfide and zinc oxide
In the present work, we report a novel design and preparation for the mechanochemical synthesis of calcium carbide-derived carbon (CaC2-CDC) at ambient temperature. Thermodynamic calculations confirmed the possibility of calcium carbide-derived carbon formation by the reaction of calcium carbide with sulfur, iron sulfide and zinc oxide at ambient temperature. The CDCs were synthesized by the ba...
متن کاملThe Wittig Reaction
This so-called Wittig reaction has a number of advantages over other olefination methods; in particular, it occurs with total positional selectivity (that is, an alkene always directly replaces a carbonyl group). By comparison, a number of other carbonyl olefination reactions often occur with double-bond rearrangement. In addition, the factors that influence Eand Z-stereoselectivity are well un...
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ژورنال
عنوان ژورنال: OALib
سال: 2020
ISSN: 2333-9721,2333-9705
DOI: 10.4236/oalib.1106421