Mechanobiology of portal hypertension
نویسندگان
چکیده
The interplay between mechanical stimuli and cellular mechanobiology orchestrates the physiology of tissues organs in a dynamic balance characterized by constant remodeling adaptative processes. Environmental properties can be interpreted as complex set information instructions that cells read continuously, to which they respond. In liver cirrhosis, chronic inflammation injury drive dysfunction, leading excessive extracellular matrix deposition, sinusoidal pseudocapillarization, vascular occlusion parenchymal extinction. These pathological events result marked microarchitecture, is cause abnormal environmental forces, triggering sustaining long-standing progressive process fibrosis. Multiple forces such strain, shear stress, hydrostatic pressure converge at different stages disease reaching point no return where fibrosis considered non-reversible. Thereafter, reciprocal communication their niches becomes driving force for progression. Accumulating evidence supporting idea that, rather than passive consequence portal hypertension (PH), forces-mediated pathways could represent per se strategic targets novel therapeutic approaches. This manuscript aimed providing comprehensive review on PH, furnishing an introduction most important mechanisms, integrating those concepts PH pathogenesis, exploring possible scenarios upcoming strategies.
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ژورنال
عنوان ژورنال: JHEP reports
سال: 2023
ISSN: ['2589-5559']
DOI: https://doi.org/10.1016/j.jhepr.2023.100869