Mechanistic investigation of aziridine aldehyde-driven peptide macrocyclization: the imidoanhydride pathway

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Mechanistic investigation of aziridine aldehyde-driven peptide macrocyclization: the imidoanhydride pathway

Davenport Research Laboratories, Departme St. George Street, Toronto, Ontario M5S utoronto.ca Encycle Therapeutics Inc., 101 College Stre Canada Center for Structural Investigations of Co Department of Chemistry, University of T Ontario M5S 3H6, Canada † Electronic supplementary information ( and characterization data. CCDC 14 crystallographic data in CIF or o 10.1039/c5sc01958c Cite this: Chem...

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Peptide macrocycles have found applications that range from drug discovery to nanomaterials. These ring-shaped molecules have shown remarkable capacity for functional fine-tuning. Such capacity is enabled by the possibility of adjusting the peptide conformation using the techniques of chemical synthesis. Cyclic peptides have been difficult, and often impossible, to prepare using traditional syn...

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Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics

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ژورنال

عنوان ژورنال: Chemical Science

سال: 2015

ISSN: 2041-6520,2041-6539

DOI: 10.1039/c5sc01958c