Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease

Biomarkers of Cardiovascular Disease

Proteomics-based development of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights.

Cardiovascular disease remains a paramount focus of basic science and clinical investigation throughout the developed world, although the demographics have changed considerably in the later half of the 20th century. Atherosclerotic cardiovascular disease, especially ischemic heart disease, has emerged as the major concern, while rheumatic fever and its cardiac sequelae have been superseded by c...

Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease : Mechanistic , Research , and Clinical Considerations for Youth

The rapid increase in the prevalence and severity of obesity in children is likely to lower the age of onset and increase the incidence of cardiovascular disease worldwide. Understanding the pathophysiology and improving the clinical management of cardiovascular disease involve a knowledge of novel risk factors and biomarkers. The clinical and mechanistic roles of these novel biological factors...

Circulating Biomarkers in Cardiovascular Disease

According to the Merriam-Webster Online Dictionary, a biomarker is ‘a distinctive biological or biologically derived indicator (as a metabolite) of a process, event, or condition (as aging, disease, or oil formation)’ [1]. A biomarker can be structural, such as mammography or a coronary calcium scan, or functional, such as glomerular filtration rate or blood pressure, but the term biomarker is ...

Vascular biomarkers and surrogates in cardiovascular disease.

Cardiovascular biomarker research efforts have resulted in the identification of new risk factors and novel drug targets, as well as the establishment of treatment guidelines. Government agencies, academic research institutions, diagnostic industries, and pharmaceutical companies all recognize the importance of biomarkers in advancing therapies to improve public health. In drug development, bio...