Mechanisms underlying FeCl3-induced arterial thrombosis

The Myosin II Inhibitor, Blebbistatin, Ameliorates FeCl3-induced Arterial Thrombosis via the GSK3β-NF-κB Pathway

Arterial thrombosis and its related diseases are major healthcare problems worldwide. Blebbistatin is an inhibitor of myosin II, which plays an important role in thrombosis. The aim of our study is to explore the effect and potential mechanism of blebbistatin on arterial thrombosis. A ferric chloride (FeCl3) solution at a concentration of 5% was used to induce carotid artery thrombosis in mice....

Physiochemical artifacts in FeCl3 thrombosis models.

In this issue of Blood, Ciciliano et al demonstrate that thrombus formation in ferric chloride (FeCl3) thrombosis models relies on physiochemical, rather than biological, mechanisms.

Mechanisms Underlying Leptin- induced Cardioprotection

Introduction Activation of the Reperfusion Injury SalvageKinase (RISK) pathway, which incorporates phosphatidyli-nositol-3-OH kinase (PI3K)-Akt/protein kinase B (PKB) andp44/42 mitogen-activated protein kinase (MAPK), underliesprotection against ischemia–reperfusion (I/R) injury. Thetemporal nature of the activation of these RISK pathwaycomponents during reperfusion ...

Mechanisms Underlying Aggregation Induced Immunogenicity

The Molecular Genetics and Cellular Mechanisms Underlying Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is an incurable disorder clinically characterised by a sustained elevation of mean arterial pressure in the absence of systemic involvement. As the adult circulation is a low pressure, low resistance system, PAH represents a reversal to a foetal state. The small pulmonary arteries of patients exhibit luminal occlusion resultant from the uncontrolled growth ...