Mechanisms of the 14-3-3 Protein Function: Regulation of Protein Function Through Conformational Modulation
نویسندگان
چکیده
منابع مشابه
Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation.
Many aspects of protein function regulation require specific protein-protein interactions to carry out the exact biochemical and cellular functions. The highly conserved members of the 14-3-3 protein family mediate such interactions and through binding to hundreds of other proteins provide multitude of regulatory functions, thus playing key roles in many cellular processes. The 14-3-3 protein b...
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15 صفحه اولStructural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function.
Phosducin (Pdc) is a conserved phosphoprotein that, when unphosphorylated, binds with high affinity to the complex of βγ-subunits of G protein transducin (Gtβγ). The ability of Pdc to bind to Gtβγ is inhibited through its phosphorylation at S54 and S73 within the N-terminal domain (Pdc-ND) followed by association with the scaffolding protein 14-3-3. However, the molecular basis for the 14-3-3-d...
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The aim of this study to review an overview of the current information on the structure of proteins 14-3-3 and their complexes, in addition to that it provides insights into the mechanisms of their functions. The 14-3-3 proteins are from families maintain regulatory molecules expressed in all eukaryotic cells. It was discovered before thirty years, it is attributes of 14-3-3 proteins are able t...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2014
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.932659