Mechanisms of Stroke Induced Neuronal Death: Multiple Therapeutic Opportunities

Mechanisms of Stroke Induced Neuronal Death: Multiple Therapeutic Opportunities

August 2014 | Volume 2 | Issue 8 | Page 438 Abstract | Stroke is one of the major contributors of mortality and morbidity worldwide. It results due to sudden blockade of blood flow into the brain thereby leading to breakdown of hemodynamic, biochemical and metabolic processes in the affected territory. These alterations are dependent on the severity and duration of the ischemia and modulated by...

Neuronal death in Alzheimer’s disease and therapeutic opportunities

Alzheimer's disease (AD) is an age-related neurodegenerative disease that affects approximately 24 million people worldwide. A number of different risk factors have been implicated in AD; however, neuritic (amyloid) plaques are considered as one of the defining risk factors and pathological hallmarks of the disease. In the past decade, enormous efforts have been devoted to understand the geneti...

Neuronal death and survival - targeting glutamate-induced cell death mechanisms

Mechanisms of Ischemic Induced Neuronal Death and Ischemic Tolerance

Stroke is the second leading cause of death and the primary cause of disability in humans. The phenomenon of ischemic tolerance perfectly describes the quote: “What does not kill you makes you stronger.’’ Ischemic preor postconditioning is actually the strongest known procedure to prevent or reverse delayed neuronal death. It works specifically in sensitive vulnerable neuronal populations, whic...

O9: Mechanisms and Therapeutic Options in Multiple Sclerosis

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system associated to myelin loss and neurodegeneration. Clinically patients suffer from diverse symptoms and face the risk to become wheelchair-bound. At the moment MS is incurable, thus there is an unmet need for therapeutic options.