Mechanisms of Selective Anticancer Action of Histone Deacetylase Inhibitors
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چکیده
منابع مشابه
Histone deacetylase inhibitors as novel anticancer therapeutics
Histone deacetylase inhibitors represent a promising new class of compounds for the treatment of cancer. Inhibitors of this kind currently under clinical evaluation mainly target the classical (Rpd3/Hda1) family of histone deacetylases. Of particular note, the U.S. Food and Drug Administration recently approved the first histone deacetylase inhibitor (Zolinza: Merck and Co., Whitehouse Station,...
متن کاملHistone deacetylase inhibitors (HDACIs): multitargeted anticancer agents
Histone deacetylase (HDAC) inhibitors are an emerging class of therapeutics with potential as anticancer drugs. The rationale for developing HDAC inhibitors (and other chromatin-modifying agents) as anticancer therapies arose from the understanding that in addition to genetic mutations, epigenetic changes such as dysregulation of HDAC enzymes can alter phenotype and gene expression, disturb hom...
متن کاملHistone Deacetylase Inhibitors as Anticancer Drugs
Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT). HDAC inhibitors induce cancer cell cycle arrest, differentiation and cell death, redu...
متن کاملInhibitors of histone deacetylase are potentially effective anticancer agents.
During the past decade, a number of HDAC inhibitors have been identified that induce tumor cells in culture and in tumor-bearing animals to undergo growth arrest, differentiation, and/or apoptotic cell death (1). Acetylation and deacetylation of histones, part of the core proteins of nucleosomes, play an important role in the regulation of gene expression (2). There are two classes of enzymes i...
متن کاملAction mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies
Histone deacetylases (HDACs) critically regulate gene expression by determining the acetylation status of histones. Studies have increasingly focused on the activities of HDACs, especially involving non-histone proteins, and their various biological effects. Aberrant HDAC expression observed in several kinds of human tumors makes HDACs potential targets for cancer treatment. Several preclinical...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2005
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.4.6.1717