Mechanisms of oxidative stress and myocardial protection during open-heart surgery

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Mechanisms of oxidative stress and myocardial protection during open-heart surgery

Cold heart protection via cardioplegia administration, limits the amount of oxygen demand. Systemic normothermia with warm cardioplegia was introduced due to the abundance of detrimental effects of hypothermia. A temperature of 32-33°C in combination with tepid blood cardioplegia of the same temperature appears to be protective enough for both; heart and brain. Reduction of nitric oxide (NO) co...

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Age-dependent and hypoxia-related differences in myocardial protection during pediatric open heart surgery.

BACKGROUND Current cardioplegic protection techniques used in pediatric cardiac surgery do not take into consideration age and cyanotic differences. The aim of the present work was to address this question by monitoring clinical outcome, myocardial metabolism, and reperfusion injury in pediatric patients protected by cold-crystalloid cardioplegia. METHODS AND RESULTS Fifty-eight patients (31 ...

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Perfusion During Open-Heart Surgery

PERFUSION DURING OPEN-HEART SURGERY Since the description of the Azygos factor by Andreasen and Watson in 1951, perfusion criteria have been much debated. Early investigators fluctuated between a high and low flow rates and the debate continues today. 2 · 3 ' •· 5 '" Hypothermia has been both widely acclaimed and generally repudiated. 7 • 8 Anoxic arrest of the heart' 0 ' n. z, 12 versus corona...

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Anesthesia in Cardiac Surgery (Open-Closed Heart)

In this paper the duties of an anesthesiologist and his right of i=;electing patient is discussed. La,ter, we di:=:cuss the <::mergencies cf heart surgery, pre up visit and alsc few dcails of pre up medication cf thei,e pati<mts. We also touch on the stages of anesthPsia and point to our preference for the use cf artery and vein for arterial and venous cannulation. In this paper we discuss in b...

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ژورنال

عنوان ژورنال: Annals of Cardiac Anaesthesia

سال: 2015

ISSN: 0971-9784

DOI: 10.4103/0971-9784.166465