منابع مشابه
Mechanisms of Lymphocyte Activation
The interactions of phytohemagglutinin (PHA) with normal human lymphocytes were studied utilizing radioiodinated leukoagglutinin (“$I-LPHA) over a concentration spectrum encompassing the entire range of lymphocyte metabolic responses. “jI-LPHA binding was temperature-, pH-, and time-dependent. Ligand association was rapid with at,,* of 3 to 5 min, reaching steady state in 30 min at 22”. Recepto...
متن کاملCytokines and Lymphocyte Activation
It is well known that the activation of lymphoid cells differ significantly depending on their lineage/subset and differentiation stages. Among the variety of cytokines characterized until today, essentially all the cytokines appear not to be strictly specific to any of the subset of lymphocytes. For example, all the interleukins including IL-2, IL-4 and IL-5 are not specific for B or T lymphoc...
متن کاملLymphocyte Activation Signals: Transduction
B and T lymphocytes, the antigen-specific cells of the immune system, are generally quiescent and require antigen stimulation to progress from the G0 stage of the cell cycle. The immune response to pathogens or foreign substances is initiated from clonotypic receptors on these cells that recognize the antigen and induce a series of signal transduction events. These signals are fundamental in bo...
متن کاملLymphocyte subsets and activation.
The biology of lymphocytes is regulated by a large and seemi& growing number of soluble and cell-associated species. A current list includes: interleukins IL l-7, interferons, antigen and perhaps CD4 and cytokines derived from non-lymphoid tissues such as neuropepride, steroid and admnergic hormones. The quality and quantity of regulators present in the B cell milieu during an immunologic insul...
متن کاملBiological Expressions of Lymphocyte Activation
The effects of nonspecific phytomitogens on primary plaque-forming cell (PFC) responses of mouse spleen cells to heterologous erythrocytes in vitro were studied. Spleen cell cultures treated with concanavalin A or phytohemagglutinin in vitro or established with spleen cells derived from mice injected with concanavalin A 24 h previously were similarly affected. In both cases, submitogenic doses ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1979
ISSN: 0021-9738
DOI: 10.1172/jci109280