Mechanisms of ketamine action as an antidepressant
نویسندگان
چکیده
منابع مشابه
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
Newer antidepressants are needed for the many individuals with major depressive disorder (MDD) that do not respond adequately to treatment and because of a delay of weeks before the emergence of therapeutic effects. Recent evidence from clinical trials shows that the NMDA antagonist ketamine is a revolutionary novel antidepressant because it acts rapidly and is effective for treatment-resistant...
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TO THE EDITOR Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) plays a key role in the patho-physiology of major depression, as well as the therapeutic action of antidepressants. 1,2) Serum levels of BDNF in drug naïve patients with major depression are significantly lower than those in normal controls. Additionally, serum levels of BDNF in drug naïve patients can be...
متن کاملKetamine: stimulating antidepressant treatment?
SUMMARY The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ke...
متن کاملKetamine as Antidepressant? Current State and Future Perspectives
Major depressive disorder (MDD) is a serious mental disorder that ranks among the major causes of disease burden. Standard medical treatment targeting cerebral monoamines often provides only insufficient symptom relief and fails in approximately every fifth patient. The complexity of MDD therefore, reflects more than monoaminergic dysregulation. Initial research argues the case for excessive gl...
متن کاملSustained antidepressant response to ketamine.
Case series outlining the treatment of three patients with ketamine, in which two of the patients had a sustained antidepressant effect to ketamine without the need for maintenance on antidepressants. These two responders have an established diagnosis of bipolar affective disorder with a history of response to electroconvulsive therapy and lithium, both of which have an influence on the seizure...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2018
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2017.255