Mechanisms of Isoimmunization

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Rhesus Isoimmunization and Therapeutic

SIRy-Mr. W. L. Whitehouse (21 June, p. 759), like myself' and many others, again calls attention to the potential dangers of rhesus isoimmunization in therapeutic abortion. He asks that the extent of this problem be further and scientifically investigated. There are, in fact, one or two further facets to be considered. Firstly, all of us are aware of the numbers of women whose first continuing ...

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Rhesus isoimmunization after abortion.

Out of 177 Rh(D)-negative patients studied, 96 were successfully followed-up after spontaneous or therapeutic abortion. Rh antibodies were detected by the indirect Coombs test in two patients and by an enzyme technique only in a further seven, an overall incidence of 9.4%.The prophylactic use of anti-D immunoglobulin is now recommended for Rh-negative non-immunized patients undergoing abortion,...

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Mechanisms of isoimmunization. II. Transplacental passage and postnatal survival of fetal erythrocytes in heterospecific pregnancies.

K NOWLEDGE CONCERNING the transpiacental passage of fetal erythrocytes into the maternal circulation is of critical importance for the understanding of immunologic relationships between mother and child and specifically for the mechanisms of Rh isoimmunization. In a previous study1 the phenomenon of transplacental passage was investigated in homospecific pregnancies-i.e., in the absence of mate...

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Intrauterine transfusion in Rh-isoimmunization.

Fifteen per cent. of all cases of Rh-isoimmunization end in stillbirth. Until 1963 the only available means of preventing this outcome in cases with a high risk of stillbirth was to deliver the foetus prematurely before intrauterine death had occurred. The value of this was limited, because many intrauterine deaths due to haemolytic disease of the newborn occur early in pregnancy, and because i...

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Haemostatic failure in babies with rhesus isoimmunization.

Chessells, Judith M., and Wigglesworth, J. S. (1971). Archives of Disease in Childhood, 46, 37. Haemostatic failure in babies with rhesus isoimmunization. Platelet counts, fibrinogen levels, thrombotest, thromboplastin generation screening test, thrombin ratio, and titre of circulating fibrin degradation products, were measured in 30 infants with Rh isoimmunization, of whom 5 had a bleeding ten...

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ژورنال

عنوان ژورنال: Blood

سال: 1967

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v30.6.796.796