Mechanisms of activation of innate-like intraepithelial T lymphocytes
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چکیده
منابع مشابه
NFAT2 Regulates Generation of Innate-Like CD8+ T Lymphocytes and CD8+ T Lymphocytes Responses
Nuclear factor of activated T cells (NFAT) 2 null mutant mice die in utero of cardiac failure, precluding analysis of the role of NFAT2 in lymphocyte responses. Only the NFAT2-/-/Rag-1-/- chimeric mice model gave insight into the role of NFAT2 transcription factor in T lymphocyte development, activation, and differentiation. As reports are mainly focused on the role of NFAT2 in CD4+ T lymphocyt...
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[This corrects the article on p. 486 in vol. 5, PMID: 25346734.].
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Innate lymphocytes have recently received a lot of attention. However, there are different ideas about the definition of what is "innate" in lymphocytes. Lymphocytes without V(D)J-rearranged antigen receptors are now termed innate lymphoid cells (ILCs) and include cells formerly known as natural killer (NK) cells. Also, lymphocytes that are innate should be able to recognize microbial or stress...
متن کاملIntestinal intraepithelial lymphocyte activation promotes innate antiviral resistance
Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T cell compartment, hypothesized to provide a first line of defence via cytolysis of dysregulated intestinal epithelial cells (IEC) and cytokine-mediated re-growth of healthy IEC. Here we s...
متن کاملDeficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease
BACKGROUND Based on the phenotypic and functional characteristics unconventional T-lymphocytes such as invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells link the innate and adaptive immune responses. Up to now data are scarce about their involvement in pulmonary disorders including chronic obstructive pulmonary disease (COPD). This study explores simultaneo...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2020
ISSN: 1933-0219,1935-3456
DOI: 10.1038/s41385-020-0294-6