Mechanisms Mediating Heart Rate (HR) Responses Evoked by Activation of NTS A 1 Adenosine Receptors
نویسندگان
چکیده
منابع مشابه
Mechanisms mediating regional sympathoactivatory responses to stimulation of NTS A(1) adenosine receptors.
Selective activation of adenosine A(1) and A(2a) receptors in the subpostremal nucleus tractus solitarius (NTS) increases and decreases mean arterial pressure (MAP), respectively, and decreases heart rate (HR). We have previously shown that the decreases in MAP evoked by NTS A(2a) receptor stimulation were accompanied with differential sympathetic responses in renal (RSNA), lumbar (LSNA), and p...
متن کاملActivation of NTS A(1) adenosine receptors inhibits regional sympathetic responses evoked by activation of cardiopulmonary chemoreflex.
Previously we have shown that adenosine operating via the A(1) receptor subtype may inhibit glutamatergic transmission in the baroreflex arc within the nucleus of the solitary tract (NTS) and differentially increase renal (RSNA), preganglionic adrenal (pre-ASNA), and lumbar (LSNA) sympathetic nerve activity (ASNA>RSNA≥LSNA). Since the cardiopulmonary chemoreflex and the arterial baroreflex are ...
متن کاملAdenosine receptors, heart rate, and cardioprotection.
See article by Fabritz et al. [1] (pages 500-508) in this issue. In this issue of Cardiovascular Research, a paper by Fabritz et al. [1] investigates the effects of controlled overexpression of the A3 adenosine receptor (A3AR) in the mouse heart. Their findings will feed further the current debate on the use of adenosine receptors (AR) as targets for gene therapy aimed at protecting the myocard...
متن کاملMechanisms mediating NTS P2x receptor-evoked hypotension: cardiac output vs. total peripheral resistance.
We have previously shown that P2x purinoceptor activation in the subpostremal nucleus tractus solitarius (NTS) produces dose-dependent decreases in mean arterial pressure (MAP), heart rate, efferent sympathetic nerve activity, and significant peripheral vasodilation. However, the relative roles of cardiac output (CO) and total peripheral resistance (TPR) in mediating this depressor response are...
متن کاملRole of Neurotransmitter Receptors in Mediating Light - Evoked Responses 1 in Retinal Interplexiform Cells
Role of Neurotransmitter Receptors in Mediating Light-Evoked Responses 1 in Retinal Interplexiform Cells 2 3 Zheng Jiang* and Wen Shen 4 College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431 5 *Current address: Department of Neuroscience, Johns Hopkins University, Baltimore, MD 6 21205 7 8 Running Title: Synaptic mechanism of interplexiform cells 9 10 Pages: 32 Figure...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.624.6