MECHANISM OF THYMINELESS DEATH: 73
نویسندگان
چکیده
منابع مشابه
On the mechanism of thymineless death in Bacillus subtilis.
Thymineless death (TD), the loss by a thymine-requiring auxotroph of the ability to multiply after a period of thymine starvation, was first described1 in Escherichia coli 15T-, and was attributed to "unbalanced growth," the synthesis of RNA and protein in the absence of DNA synthesis. This phenomenon has been investigated in thymineless auxotrophs of a number of bacterial species: E. coli 15Ta...
متن کاملThymineless death in Escherichia coli.
There is little doubt that thymine starvation af fects the DNA of thymine requiring bacteria1-5. However, the process of killing is fairly complicated and remains to be clarified. The genes responsible for the control of sensitivity to thymine starvation have not been identified, even though claims have been but forward for at least one gene6. Besides, whether the cells die when still in incub...
متن کاملThymineless death, at the origin
Thymineless death (TLD) in bacteria has been a focus of research for decades. Nevertheless, the advances in the last 5 years, with Escherichia coli as the model organism, have been outstanding. Independent research groups have presented compelling results that establish that the initiation of chromosome replication under thymine starvation is a key element in the scenario of TLD. Here we review...
متن کاملEnergy Requirement for Thymineless Death in Cells of Escherichia Coli.
Freifelder, David (University of California, Berkeley), and Ole Maaløe. Energy requirement for thymineless death in cells of Escherichia coli. J. Bacteriol. 88:987-990. 1964.-Thymineless death in thymine-requiring Escherichia coli is arrested immediately and reversibly by nitrogenation if the bacterial population is growing in a medium containing a carbon source that can only be metabolized aer...
متن کاملThymineless death in recombination deficient mutants of Escherichia coli K12.
When grown in thymine-free minimal synthetic medium, thyA recA mutants of Escherichia coli K12 were comparatively more resistant and thyA recBC mutants more sensitive to thymineless death (TLD) than their respective parent strains. No excessive numbers of single-strand breaks were observed in the DNA of the recBC mutant strain starved for thymine, hence the hypersensitivity for TLD in this stra...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198507000-00093