Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles
نویسندگان
چکیده
منابع مشابه
Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions.
The antifolate drug methotrexate (MTX) is transported by breast cancer resistance protein (BCRP; ABCG2) and multidrug resistance-associated protein1-4 (MRP1-4; ABCC1-4). In cancer patients, coadministration of benzimidazoles and MTX can result in profound MTX-induced toxicity coinciding with an increase in the serum concentrations of MTX and its main metabolite 7-hydroxymethotrexate. We hypothe...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2004
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-03-4062