Mechanism of relaxant effects of Clonidine in isolated bovine tracheal smooth muscle

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Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle.

The relaxant effect of clonidine and the possible involvement of imidazoline I1 receptors in bovine tracheal smooth muscle (BTSM) were examined. Clonidine caused concentration-dependent significant relaxation in BTSM precontracted with 0.1 or 1 microM carbachol (CCh) but not in 72.7 mM KCl-induced contraction. The relaxation in CCh-contracted BTSM was inhibited by yohimbine (1 microM) and idazo...

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The Differences in the Relaxant Effects of Different Fractions of Rosa damascena on Guinea Pig Tracheal Smooth Muscle

Objective(s) In the present study, the differences in the relaxant effects of aqueous, ethyl acetate and n-butanol fractions of Rosa damascena on tracheal smooth muscle of guinea pigs were examined. Materials and Methods The relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline ...

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The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms

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The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms

Crocin, a component of saffron, showed hypotensive which is perhaps due to vascular smooth muscle relaxant effect. The relaxant effects of saffron on tracheal smooth muscle also could be due to its constituent, crocin. In the present study, the relaxant effects of crocin and its possible mechanisms on rat tracheal smooth muscle were investigated. The relaxant effects of three cumulative concent...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1997

ISSN: 0021-5198

DOI: 10.1016/s0021-5198(19)45640-0