Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase
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چکیده
منابع مشابه
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase.
Activation of protein kinase B (PKB) by growth factors and hormones has been demonstrated to proceed via phosphatidylinositol 3-kinase (PI3-kinase). In this report, we show that PKB can also be activated by PKA (cyclic AMP [cAMP]-dependent protein kinase) through a PI3-kinase-independent pathway. Although this activation required phosphorylation of PKB, PKB is not likely to be a physiological s...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1999
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.19.7.4989