Mechanism of dopamine inhibition of renal phosphate transport.

Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter.

Dopamine transporters (DATs) control neurotransmitter dopamine (DA) homeostasis by reuptake of excess DA, assisted by sodium and chloride ions. The recent resolution of DAT structure (dDAT) from Drosophila permits us for the first time to directly view the sequence of events involved in DA reuptake in human DAT (hDAT) using homology modeling and full-atomic microseconds accelerated simulations....

Renalase regulates renal dopamine and phosphate metabolism.

Renalase is a kidney-secreted catecholamines-degrading enzyme whose expression and activity are downregulated by increased dietary phosphate. A renalase knockout (KO) mouse model was used to explore the mechanisms mediating renalase's effect on phosphate excretion. Compared with wild-type (WT) mice maintained on a regular diet, KO mice show decreased serum PO4(-) (KO = 5.3 ± 0.2 vs. WT = 6.0 ± ...

Dendrodendritic inhibition through reversal of dopamine transport.

Synapses in the central nervous system are usually defined by presynaptic exocytotic release sites and postsynaptic differentiations. We report here a demonstration of dendrodendritic inhibition that does not engage a conventional synapse. Using amperometric and patch-clamp recordings in rat brain slices of the substantia nigra, we found that blockade of the dopamine transporter abolished the d...

Genetic disorders of renal phosphate transport.

Inhibition of renal tubular transport of catecholamines by cocaine: an organic base mechanism.

QUEBBEMANN, Ai@ovsius ANDBARBARARENNICK: Inhibition of renal tubular transport of catecholamines by cocaine: An organic base mechanism. J. Pharmacol. Exp. Ther. 175: 248-258, 1970. The effects of cocaine on the renal excretory transport of radioactively la beled norepinephrine,epinephrine, dopamine, tyramine, m-tyramine, 3,4-dimethoxyphenyl ethylamine, phenylethylamine and tetraethylammonium we...