Mechanism of Cardiac Tropomyosin Transitions on Filamentous Actin As Revealed by All-Atom Steered Molecular Dynamics Simulations
نویسندگان
چکیده
منابع مشابه
Probing the flexibility of tropomyosin and its binding to filamentous actin using molecular dynamics simulations.
Tropomyosin (Tm) is a coiled-coil protein that binds to filamentous actin (F-actin) and regulates its interactions with actin-binding proteins like myosin by moving between three positions on F-actin (the blocked, closed, and open positions). To elucidate the molecular details of Tm flexibility in relation to its binding to F-actin, we conducted extensive molecular dynamics simulations for both...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry Letters
سال: 2018
ISSN: 1948-7185
DOI: 10.1021/acs.jpclett.8b00958