منابع مشابه
Mechanism of action of antipruritic drugs.
Astemizole and terfenadine, two potent non-sedative H1 antihistamines, had no effect on itch measured objectively as nocturnal scratching and subjectively on a 10 cm line. Trimeprazine, however, a more sedative but less potent H1 antihistamine, was antipruritic, as was nitrazepam, a sedative benzodiazepine. We concluded (a) that antipruritic drugs act centrally by a property related to sedation...
متن کامل[Mechanism of action of antiepileptic drugs].
Antiepileptic drugs (DAEs) act through different mechanisms of action: increase in central inhibition, inhibition of excitatorios mechanisms and modification of the excitability through their action on the ionic channels. Epilepsy is characterized by an abnormal and hypersynchronic unloading of a neuronal population. The activity of numerous drugs is associated to increase in gabaergic activity...
متن کاملMechanism of Action of Atypical Antipsychotic Drugs
The designation of chlorpromazine, and subsequently haloperidol, thioridazine, loxapine, thiothixene, molindone, pimozide, and related compounds as antipsychotic drugs (1) reflects their predominant action in humans, namely the suppression of auditory hallucinations and delusions, in some, but not all, individuals with diagnoses of schizophrenia as well as other psychoses. These drugs are also ...
متن کاملMechanism of action of oral antidiabetic drugs.
The fall in blood sugar with carbutamide (BZ55) 24 hr. after the maintenance dose of insulin (28.1%+/-2.9 s.e) in rabbits made severely diabetic with alloxan was significantly different from the change in the blood sugar with the same drug given 72 hr. (6.8%+/-2.0) or distilled water given 24 hr. (7.7%+/-1.3) respectively after the last dose of insulin. It is postulated that the drug acts by li...
متن کاملMechanism of Action of the Thyroid Hormone on the Heart
SUMMARY The foliowing cardiac effects may be attributed to thyroxin: 1-Thyroxin augments all anaerobic processes in the body includ::ng the heart, and decreases the glycogen content of the heart ( 1, 2, 5, 27). The resistance of the heart to anoxia is increased in hyperthyroidism ( 25). 2- Thyroxin influences the cardiac weight and prevents cardiac atrophy (3, 8, 10, 11, 19, 20, 21, 30...
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ژورنال
عنوان ژورنال: BMJ
سال: 1983
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.287.6400.1199