منابع مشابه
Mechanism of action of 5'-nucleotidase.
The enzyme 5’-nucleotidase was originally discovered in the venom of snakes (1) and later shown to be present in mammalian tissues (2-5) and bull seminal plasma (6). It has recently been extensively purified and characterized by Heppel and Hilmoe (7). The enzyme was shown to hydrolyze 5’-nucleotides rapidly, ribose-5-phosphate slowly, and other phosphate esters extremely slowly, if at all. Beca...
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Human isonucleotidases were separated by electrophoresis on a cellulose acetate membrane. Three 5'-nucleotidase forms, NTP1, NTP2, and NTP3, were resolved with this method and quantified by densitometry. The procedure was not only simple and rapid but also sufficiently precise (between-run CV < 20%) and sensitive (detected nucleotidase fractions of > 0.5 U/L). The effects of various treatments ...
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5-Aminosalicylic Acid (5-ASA) has been used for over 50 years in the treatment of inflammatory bowel disease in the pro-drug form sulphasalazine (SASP). SASP is also used to treat rheumatoid arthritis. However whether the therapeutic properties of SASP are due to the intact molecule, the 5-ASA or sulphapyridine components is unknown. Several mechanisms of action have been proposed for 5-ASA and...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1956
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65265-2