Mechanism-Based Inactivation of Cytochrome P450 2B6 by Methadone through Destruction of Prosthetic Heme
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چکیده
منابع مشابه
Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.
Methadone is a μ-opioid receptor agonist widely used in the treatment of narcotic addiction and chronic pain conditions. Methadone is metabolized predominantly in the liver by cytochromes P450 to its pharmacologically inactive primary metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine. Initial in vitro data suggested that CYP3A4 is the major isoform responsible for the in vivo clearan...
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This article has not been copyedited and formatted. The final version may differ from this version. #42176 3 ionization; LC-MS, liquid chromatography-mass spectrometry; LC-MS/MS, liquid chromatography-tandem mass spectrometry. This article has not been copyedited and formatted. The final version may differ from this version. Abstract The mechanism-based inactivation of human CYP2B6 by tert-buty...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2012
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.112.045971