Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain
نویسندگان
چکیده
منابع مشابه
Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain
Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development. Since NGF blocking is an eff...
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BACKGROUND Nerve growth factor (NGF) is not only an important factor in nerve growth but also a major contributor to the production of inflammation. It has been reported that inhibiting NGF could reduce several types of pain in several animal models. Here, we aimed to clarify the efficacy of NGF antibody in a knee osteoarthritis (OA) pain model in mice. METHOD Six-week-old male C57BR/J mice w...
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ژورنال
عنوان ژورنال: Therapeutics and Clinical Risk Management
سال: 2017
ISSN: 1178-203X
DOI: 10.2147/tcrm.s139814