Mechanism Analysis of Vascular Calcification Based on Fluid Dynamics

Vascular calcification is the abnormal deposition of calcium phosphate complexes in blood vessels, which regarded as pathological basis multiple cardiovascular diseases. The flowing exerts a frictional force called shear stress on vascular wall. Blood vessels have different hydrodynamic properties due to discrepancies geometric and mechanical properties. disturbance flow bending area branch point arterial tree produces lower than physiological magnitude laminar stress, can induce occurrence calcification. Endothelial cells sense fluid dynamics transmit electrical chemical signals full-thickness vessels. Through crosstalk with endothelial cells, smooth muscle trigger osteogenic transformation, involved mediating intima media In addition, based detection parameters, emerging imaging technologies such 4D Flow MRI computational greatly improved early diagnosis ability diseases, showing extremely high clinical application prospects.