Mechanical softness: a true stemness feature for cancer cells
نویسندگان
چکیده
منابع مشابه
Cancer stem cells: a shifting subpopulation of cells with stemness?
Carcinogenesis and tumor cells had long been thought to be produced by genetic mutations, until the emergence of the cancer stem cell (CSC) model. This relatively new model reveals another layer of complexity in malignancy formation and maintenance. However, these hard-to-track subpopulations have not only been challenging to understand at the molecular level but have also prevented the develop...
متن کاملStemness is Derived from Thyroid Cancer Cells
BACKGROUND One hypothesis for thyroid cancer development is its derivation from thyroid cancer stem cells (CSCs). Such cells could arise via different paths including from mutated resident stem cells within the thyroid gland or via epithelial to mesenchymal transition (EMT) from malignant cells since EMT is known to confer stem-like characteristics. Furthermore, EMT is a critical process for ep...
متن کاملIonizing Radiation Induces Stemness in Cancer Cells
The cancer stem cell (CSC) model posits the presence of a small number of CSCs in the heterogeneous cancer cell population that are ultimately responsible for tumor initiation, as well as cancer recurrence and metastasis. CSCs have been isolated from a variety of human cancers and are able to generate a hierarchical and heterogeneous cancer cell population. CSCs are also resistant to convention...
متن کاملReversing cancer stemness
lethality of malignant breast cancer in human patients. Although various targeted and non-targeted therapies can occasionally control the progress of breast cancer, a significant portion of patients develop resistance to chemotherapy and experience metastatic recurrence. The epithelial to mesenchymal transition (EMT), a key developmental program in embryogenesis, has been found to be closely in...
متن کاملthe pluripotency feature of cancer cells; product of a harmony or an output of a disharmony
pluripotency is a central feature of stem and cancer cells. this feature enables cancer cells to self-renew and trans-differentiate. in this editorial, it is hypothesized that in cancer cells synchronized events rather than segmented procedures may lead to pluripotency.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2021
ISSN: 2372-3556
DOI: 10.1080/23723556.2021.1882285