Mechanical Aspects of Protein Thermostability

The Upper Limit of Protein Thermostability

Bioinformatics-driven, rational engineering of protein thermostability.

A longstanding goal in protein engineering is to identify specific sequence changes that endow proteins with desired functional properties. As opposed to traditional rational and random protein engineering techniques, we have employed a bioinformatic approach to identify specific sequence changes that influence key functional properties of a protein within a defined superfamily. Specifically, w...

prediction of protein thermostability by an efficient neural network approach

introduction: manipulation of protein stability is important for understanding the principles that govern protein thermostability, both in basic research and industrial applications. various data mining techniques exist for prediction of thermostable proteins. furthermore, ann methods have attracted significant attention for prediction of thermostability, because they constitute an appropriate ...

Biochemical Aspects of Protein Changes in Seed Physiology and Germination

Seed storage proteins are synthesized as sources of carbon, nitrogen and sulfur for the next generation of plants. Reactive oxygen species serve as second messengers for signal transduction; however, molecular targets of oxidant signaling have not been defined. Here, many researchers showes that ligand–receptor mediated signaling promotes reactive oxygen species– dependent protein carbonylation...

Biochemical Aspects of Protein Changes in Seed Physiology and Germination

Seed storage proteins are synthesized as sources of carbon, nitrogen and sulfur for the next generation of plants. Reactive oxygen species serve as second messengers for signal transduction; however, molecular targets of oxidant signaling have not been defined. Here, many researchers showes that ligand–receptor mediated signaling promotes reactive oxygen species– dependent protein carbonylation...