Measurements of 5-FU Plasma Concentrations in Patients with Gastrointestinal Cancer: 5-FU Levels Reflect the 5-FU Dose Applied
نویسندگان
چکیده
منابع مشابه
Measurements of 5-FU Plasma Concentrations in Patients with Gastrointestinal Cancer: 5-FU Levels Reflect the 5-FU Dose Applied
Introduction: 5-Fluorouracil (5-FU) is the basis of most combination chemotherapies for gastrointestinal tumors. It is generally well tolerated, but side-effects might require dose-adjustment. As adverse events are not specific to the 5-FU component of the chemotherapy-combination, i.e. neutropenia, diarrhea or cardiotoxicity, the knowledge of 5-FU serum levels might help to attribute these sid...
متن کامل5-FU schedules, serum 5-FU levels and their relationship to therapy response and toxicity in patients with gastrointestinal cancer.
Correspondence to Dr. Silke Cameron, MD Department of Gastroenterology and Endocrinology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany silke.cameron@med. uni-goettingen.de
متن کاملMenthol towards 5-FU
Borneol and menthol were two terpenes wildly used as penetrate enhancer in 14 transdermal drug delivery. To explore their penetration enhancement effect towards hydrophilic 15 drug, 5-FU was selected as model drug. A method combined vitro permeation studies and coarse 16 grain molecular dynamics was used to investigate their penetration enhancement effect towards 17 5-FU. As a result, although ...
متن کاملEvaluation of 5-FU plasma concentration by 13C breath test in patients treated with oral 5-FU analogs.
BACKGROUND/AIM The objective of this study was to investigate the influence of digestive gastrointestinal absorption function on the pharmacokinetics of the orally-administered anticancer drug, Tegafur-gimestat-otastat potassium (TS-1), by measuring the plasma 5-fluorouracil (5-FU) concentration using stable isotope breath tests. PATIENTS AND METHODS Twenty-nine patients with progressive/recu...
متن کامل5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs
5-Fluorouracil (5-FU) is a key anticancer drug that for its broad antitumor activity, as well as for its synergism with other anticancer drugs, has been used to treat various types of malignancies. In chemotherapeutic regimens, 5-FU has been combined with oxaliplatin, irinotecan and other drugs as a continuous intravenous infusion. Recent clinical chemotherapy studies have shown that several of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cancer Therapy
سال: 2012
ISSN: 2151-1934,2151-1942
DOI: 10.4236/jct.2012.31004