Measurement of myocardial perfusion with positron emission tomography and generator-produced Copper-62-PTSM
نویسندگان
چکیده
منابع مشابه
Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography.
BACKGROUND Noninvasive assessment of regional myocardial perfusion at rest and after stress is important for the objective evaluation of the effects of coronary artery disease and its response to therapy. Centers that do not have cyclotrons rely on generator-produced radioisotopes for assessment of regional myocardial perfusion with positron emission tomography (PET). The aim of the present stu...
متن کاملAssessment of regional myocardial and renal blood flow with copper-PTSM and positron emission tomography.
We recently demonstrated in isolated, perfused hearts that radiolabeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II) (Cu-PTSM) is well extracted throughout a range of conditions including ischemia, hypoxia, and hyperemia. Once extracted, binding of radioactivity by the isolated heart was essentially irreversible, giving this tracer microspherelike qualities. Because Cu-PTSM can be ...
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Positron emission tomography (PET) was applied to the measurement of myocardial perfusion using the perfusion tracer 13N-labeled ammonia. 13N ammonia was delivered intravenously to 13 healthy volunteers both at rest and during supine bicycle exercise. Dynamic PET imaging was obtained in three cross-sectional planes for 10 minutes commencing with each injection. The left ventricle was divided in...
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Cardiac positron emission tomography (PET) imaging is a well-validated, reimbursable means to assess myocardial perfusion, left ventricular (LV) function, and viability. Presently, there is a proliferation of PET and PET/computed tomography (CT) instrumentation as well as an increase in educational programs that specifically address PET and PET/CT imaging. Technologists performing PET scans as ...
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Background—Positron-emission tomography (PET) tracers for myocardial perfusion are commonly labeled with short-lived isotopes that limit their widespread clinical use. F-BMS-747158-02 (F-BMS) is a novel pyridaben derivative that was evaluated for assessment of myocardial perfusion by comparison with N-ammonia (NH3) and with radioactive microspheres in a pig model. Methods and Results—Fourteen p...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1990
ISSN: 0735-1097
DOI: 10.1016/0735-1097(90)92038-4