Measurement of gastrointestinal and colonic transit in mice

Measurement of Colonic Transit

An abnormality in transit is commonly considered to account for unexplained gastrointestinal (GI) symptoms. This review describes the most commonly used methods for the measurement of GI transit including small bowel transit test for dyspeptic symptoms and diarrhea, colonic transit test for constipation. Colonic transit times can help uncover causative diagnoses by stratifying motility disorder...

Measurement of colonic transit time with Transit-PelletsmethodTM

About 20% of the population suffer from constipation. For the common types of functional constipation, idiopathic and IBS related constipation, the proportion of women is about 80-90%. It is important to structure the management of this large patient group. The duration of symptoms is of relevance. In general, a long history allows for more restricted investigations, and the management can be f...

Measurement of gastrointestinal transit using radioactive chromium.

Simplified method for the measurement of segmental colonic transit time.

Segmental colonic transit has been measured in 101 patients. Two MBq of 111Indium absorbed on resin pellets and encapsulated in an enteric coated capsule was given at 7 00 am. Hourly images during the first day, and three images during each subsequent day were acquired for up to three days. Using all scan and patient data the scans were categorised in one of the five patterns of colonic transit...

Scintigraphic measurement of regional gastrointestinal transit in the dog.

Scintigraphic techniques can measure sequentially gastric emptying, small bowel transit, and colonic transit in humans, and comparable methods for experimental studies in animals would be useful. We developed such a method in dogs and examined the effects of prokinetic drugs on regional transit. Two isotopes were given to fasting dogs. Polystyrene pellets labeled with99mTc were mixed in a can o...