Measurement of Gamma Glutamyl Transferase to Determine Risk of Liver Transplantation or Death in Patients With Primary Biliary Cholangitis

Background & AimsGamma-glutamyltransferase (GGT) is a serum marker of cholestasis. We investigated whether level GGT prognostic for patients with primary biliary cholangitis (PBC).MethodsWe analyzed data from PBC the Global Study Group, comprising 14 centers in Europe and North America. obtained measurements at baseline time points after treatment. used Cox model hazard ratios to evaluate association between clinical outcomes, including liver transplantation liver-related death.ResultsOf 2129 included our analysis, 281 (13%) had endpoint. Mean age diagnosis was 53 years 91% were female patients. found correlation levels alkaline phosphatase (ALP) (r = 0.71). Based on collected yearly up 5 years, higher associated lower transplant-free survival. Serum 12 months treatment than 3.2-fold upper limit normal (ULN) identified who required or death 10 an area under receiver operating characteristic curve 0.70. The risk above ULN, despite ALP 1.5-fold compared ULN (P < .05). Including information increased value Globe score.ConclusionsSerum can be identify death, increase measurement. Our findings support use as endpoint trials. In low ALP, high identifies those might require metabolic disorders escalation. Gamma-glutamyltransferase (PBC). death. Of score.