منابع مشابه
Antigenic determinants of measles virus hemagglutinin associated with neurovirulence.
The biological activity of monoclonal antibodies specific for the hemagglutinin protein of measles virus strain CAM recognizing six epitope groups according to their binding properties to measles virus strain CAM/R401 was investigated in vivo in our rat model of measles encephalitis. When injected intraperitoneally into measles virus-infected suckling rats, some monoclonal antibodies modified t...
متن کاملMeasles Virus Hemagglutinin Protein Epitopes: The Basis of Antigenic Stability
Globally eliminating measles using available vaccines is biologically feasible because the measles virus (MV) hemagglutinin (H) protein is antigenically stable. The H protein is responsible for receptor binding, and is the main target of neutralizing antibodies. The immunodominant epitope, known as the hemagglutinating and noose epitope, is located near the receptor-binding site (RBS). The RBS ...
متن کاملPurification and Some Antigenic Properties of Measles Virus Hemagglutinin.
PeriesとChanyら (1960) が麻 疹 ウイル スが, ba boon erythrocytesを 凝集す る ことを初めて報告 して以来 この ウイルス の赤血球凝集素 (HAnin) の研究がかな り 進 められ てきた. Funahashiら (1963) は猿血球 の中で も種 に よ りウイ ル スに対す る感受性 にかな り差がみ られ, なかで もgreen monkeyとrhesus monkeyの 血球 は感受性 が高 く個 体 差 も少 ないが, cynomolgus monkeyの 血球は感受性 は 一 般 に低 く個体差 が多い こと , 及び麻疹 ウイル スをエー テルTween 80処 理す る と赤血球凝集価 (HA価) が上昇 し, この もの を庶糖濃度勾配又 はCsCl濃 度勾配平衡遠 心 法 な どによ り超遠心 する とHA nin...
متن کاملImmune reactivity of the purified hemagglutinin of measles virus.
The role of the immune response to measles virus in acute infection or in disease states associated with this virus is of major interest. The viral genome-specified surface antigens of measles, the hemagglutinin and fusion proteins, are likely to be of paramount importance with respect to the host immune response to the virus. This report describes initial studies aimed at assessing the immune ...
متن کاملMeasles Virus Hemagglutinin: Structural Insights into Cell Entry and Measles Vaccine
Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glycoproteins, the hemagglutinin (H) and the fusion (F)...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1986
ISSN: 0014-5793
DOI: 10.1016/0014-5793(86)80668-8