Measles Resurgence and Drug Development

Global reductions in measles mortality 2000-2008 and the risk of measles resurgence.

Resurgence of measles virus in São Paulo, Brazil.

The epidemic that occurred in SP in 1997 showed the circulation of the D6 group. After this period there was a decrease in the individuals susceptible to it. Due to good strategies for the close observation of measles virus, the circulation of indigenous cases was not registered for the mentioned period. However, in 2001, 2002 and 2005, cases of an imported virus belonging to the group D5 was r...

Measles resurgence following a nationwide measles vaccination campaign in Nigeria, 2005-2008.

INTRODUCTION From 1990 through 2008, routine immunization coverage of measles vaccine in Nigeria ranged from 35% to 70%. Nigeria conducted a nationwide measles vaccination campaign in 2 phases during 2005-2006 that targeted children aged 9 months to 14 years; in 2008, a nationwide follow-up campaign that targeted children aged 9 months to 4 years was conducted in 2 phases. Despite these efforts...

Saturated treatments and measles resurgence episodes in South Africa: a possible linkage.

We consider the case of measles in South Africa to show that an high vaccination coverage may be not enough - alone - to ensure measles eradication. The occurrence of certain epidemic episodes may in fact be encouraged by delays in the treatments or by not adequately fast clinical case management, which may be related to the backward bifurcation phenomenon as well as to an intriguing spiking dy...

Assessing the risk of measles resurgence in a highly vaccinated population: Belgium anno 2013.

Despite long-standing two-dose measles-mumps-rubella (MMR) vaccination, measles outbreaks still occur in highly vaccinated European populations. For instance, large measles outbreaks occurred in France (2008–13), the United Kingdom (2012–13) and the Netherlands (2012). Based on a multicohort model approach, using spatial serological survey data, MMR vaccination coverage data and data on social ...