MDM2 SNP309 polymorphism in Turkish population
نویسندگان
چکیده
منابع مشابه
MDM2 SNP309 polymorphism is associated with colorectal cancer risk
The human murine double minute 2 (MDM2) is known as an oncoprotein through inhibiting P53 transcriptional activity and mediating P53 ubiquitination. Therefore, the amplification of MDM2 may attenuate the P53 pathway and promote tumorigenesis. The SNP309 T>G polymorphism (rs2279744), which is located in the intronic promoter of MDM2 gene, was reported to contribute to the increased level of MDM2...
متن کاملCorrelations between MDM2 gene SNP309 Polymorphism and Susceptibility to Leukemia
BACKGROUND The objective of this study was to perform a systematic review of correlations between the single-nucleotide polymorphism at nucleotide 309 (single-nucleotide polymorphism, SNP309) in the murine double-minute 2 (MDM2) gene promoter and susceptibility to leukemia. MATERIAL/METHODS We performed a computer search of relevant case-control studies published from January 1990 to Jan 2014...
متن کاملMDM2 SNP309 polymorphism is associated with lung cancer risk in women: A meta-analysis using METAGEN
Lung cancer is the most common diagnosed malignancy and the leading cause of cancer-related mortality worldwide. Murine double minute 2 (MDM2) SNP309 polymorphisms have been reported to influence the risk of lung cancer. However, the published studies together with four subsequent meta-analyses have yielded contradictory results. To examine this inconsistency, we conducted a meta-analysis of 6,...
متن کاملAssociation between MDM2 SNP309 polymorphism and endometrial cancer risk in Polish women.
The prognostic value of the MDM2 gene amplification/expression in many types of cancer remains unclear. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter the protein expression and thus, may play a role in carcinogenesis. The aim of the present study was to evaluate the association between the risk of endometrial cancer and SNP309 polymorphisms in the MDM2 gene. Th...
متن کاملInvolvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer.
The allelic variant MDM2-SNP309 (T>G) has been suggested to influence cancer development, but the clinical correlation between the risk allele and breast cancer remains controversial. The genetic background and the ethnicity of selected subgroups may influence the power of these risk genotypes. In this study, we investigated whether MDM2-SNP309 is associated with p53 R72P genetic polymorphism f...
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ژورنال
عنوان ژورنال: Cumhuriyet Medical Journal
سال: 2017
ISSN: 1305-0028
DOI: 10.7197/223.v39i32356.369012